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KMID : 0370220110550050367
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Yakhak Hoeji
2011 Volume.55 No. 5 p.367 ~ p.373
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Synthesis of Anti-inflammatory 2’-Hydroxychalcone Derivatives
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Lee Young-Sook
Kim Hak-Sung
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Abstract
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It was reported that the potency of TMMC derivatives was related to the presence of the 2’-hydroxy group on the A ring. Also, 4-dimethylamino group on the B ring lowered the anti-inflammatory potency of the chalcones. We synthesized various derivatives of 2’-hydroxy chalcones having other substituents on B ring. The synthetic derivatives showed the more potent anti-inflammatory effect, comparable to that of the TMMC derivatives reported previously.
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KEYWORD
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chalcone, 2’-hydroxy group, anti-inflammatory, TMMC
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